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A definitive diagnosis may be hampered by coexisting blood loss, the effects of medications, or inborn errors of hemoglobin synthesis such as thalassemia. The change in the primary end point was made to clarify this role. Statistical Analysis Epidemiologic data suggested that the treatment-related difference in LDL cholesterol levels between the two groups would translate into 20 to 30 percent fewer recurrent coronary events at five years in the group given 80 mg of atorvastatin than in the group given 10 mg of atorvastatin. Waters, San Francisco; N. As compared with patients given 10 mg of atorvastatin, patients given 80 mg of atorvastatin also had significant reductions in the risk of a Mature Nude Swingers coronary event hazard ratio, 0.

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In summary, our findings demonstrate that the use of an mg dose of atorvastatin to reduce LDL cholesterol levels to 77 mg per deciliter provides additional clinical benefit in patients with stable CHD that is perceived to be well controlled at an LDL level of approximately mg per deciliter. If these results were extrapolated to clinical practice, the use of an mg dose of atorvastatin to reduce LDL cholesterol levels from a baseline of mg per deciliter to 77 mg per deciliter in patients with stable CHD would prevent 34 major cardiovascular events over a period of five years; in other words, approximately 30 patients would need to be treated to prevent one event. A prospective, multicenter trial involving patients who are undergoing dialysis — a study of an intervention that is designed to achieve normal hematocrit levels above 42 percent , as compared with lower levels above 30 percent , with the use of a combination of erythropoietin therapy and intravenous iron dextran — was halted because of increased mortality in the high-hematocrit cohort. Both doses of atorvastatin produced nonsignificant increases over baseline in high-density lipoprotein HDL cholesterol levels, with no significant difference between the groups during the course of the study Figure 2D.
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